Endocrine Abstracts

Six years after hemorrhagic fever with renal syndrome (HFRS) 73 years old man was admitted in hospital because of hyponatremia (Na 129 mmol/l) and abdominal pain. Before HFRS he was treated for pancreatitis, hypertension, ulcerative colitis and gallstones. In the year 2002 he was admitted with fiver, vomiting, diarrhoea, headache and blurred vision. Serologic immunoflourescence testing was positive for Hantaan (Puumala) virus. During the hospital course haemodialysis was neces...

Objective: In this study we analysed the prediabetes incidence in women with polycystic ovary syndrome (PCOS), as well as prediabetes and cardiovascular disease (CVD) risk factors in women with PCOS.Methods: This study included 148 women with PCOS, with no type 2 diabetes mellitus (T2DM) and CVD present at the baseline. We determined a comprehensive panel of biochemical parameters, including lipid profile, glucose and insulin levels during oral glucose t...

Introduction: Myotonic dystrophy type 1 (DMT1) is the most prevalent muscular dystrophy that affects 1 in 8000 individuals. Disease is caused by CTG repeat expansion of the DMPK gene located on chromosome 19. Beside neuromuscular involvement, studies have found an increased prevalence of endocrinopathies such as diabetes, hyperparathyroidism and hypogonadism. The exact underlying mechanism of endocrine dysfunction remains unclear. Moreover, endocrine dysfunction is progressive...

Background and aims: To assess the prevalence and variability of pathogenic or likely pathogenic autosomal dominant mutations (ADM) of Familial Hypercholesterolemia (FH) in a Finnish cohort of patients with premature coronary artery disease (CAD) and elevated LDL-C levels.Methods: Study population was enrolled from 162 patients diagnosed with premature CAD (men < 55 years and women < 60 years) and history of high LDL-C (≥ 5 mmol/l) levels, ...

Objectives: Maternal metabolism has a major impact on foetal growth, and the risk of developing obesity, cardiovascular disease and diabetes in later life. Identification of maternal metabolic parameters in early pregnancy that predict birth weight (BW), is pivotal in the prevention of these diseases. We evaluated whether maternal triglyceride (TG) or fructosamine levels in early pregnancy, as possible reflectors of maternal insulin resistance (IR), could predominantly contrib...

Familial hypercholesterolemia (FH) remains underdiagnosed in general population. Screening programs in unselected individuals have shown modest results in identifying patients with FH. Incidence of FH is higher in young patients with coronary artery disease (CAD), especially when associated with high LDL-cholesterol levels. Targeted screening in this population could add value to FH-index patient identification. We have established an IT-based automated screening tool to enhan...

Animals that are not exposed to endogenous sex steroids during development provide an important model for studying hormone independent development of brain sex differences. Due to gonadal agenesis, male and female steroidogenic factor 1 knockout (SF-1 KO) mice are born phenotypically female. Normally, they die shortly after birth due to adrenal insufficiency. Early corticosteroid injections followed by adrenal transplantation can maintain SF-1 KO mice into adulthood. As severa...

Background: Medullary thyroid cancer is a rare neuroendocrine neoplasm that can secrete variety of hormones, including ACTH. Cushing syndrome due to ectopic ACTH secretion is a rare complication of medullary thyroid cancer, usually accociated with metastatic disease. Around 50 percent of patients with medullary thyroid carcinoma and ectopic Cushing syndrome die due to complications of hypercortisolism. Based on the aforementioned, efficient management of hypercortisolism is cr...

Background: Radiotherapy (conventional and/or radiosurgery) is an effective treatment option in patients with acromegaly when biochemical control of the disease cannot be achieved by medication and/or surgery. Purpose: The aim of our study was to evaluate the efficacy of gamma-knife radiosurgery or conventional radiotherapy in the treatment of GH-secreting pituitary adenomas.Materials and methods: We conducted a retrospective analysis of 22 acromegaly pa...

Introduction: The standard management of Graves’ disease includes initial use of antithyroid drugs, while radioactive iodine ablation or thyroid surgery are later definitive treatment options. Management of thyrotoxicosis secondary to the use of amiodarone can be challenging as patients may not promptly respond to antithyroid or corticosteroid therapy, and thyrotoxicosis may be more harmful in those patients owing to the underlying cardiac disease. In rare thyrotoxicosis ...